Hyong Joo Lee Selected Research

daidzein

4/2011	7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.
4/2011	6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.
11/2007	Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway.

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Hyong Joo Lee Research Topics

Disease

63	Neoplasms (Cancer) 05/2016 - 02/2002
24	Carcinogenesis 06/2013 - 01/2002
13	Inflammation (Inflammations) 05/2016 - 10/2005
11	Skin Neoplasms (Skin Cancer) 01/2014 - 07/2008
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2014 - 11/2005
9	Neoplastic Cell Transformation 05/2016 - 09/2007
7	Obesity 10/2017 - 01/2013
7	Atherosclerosis 05/2014 - 01/2006
7	Alzheimer Disease (Alzheimer's Disease) 02/2014 - 01/2007
7	Hepatocellular Carcinoma (Hepatoma) 07/2008 - 01/2006
6	Neoplasm Metastasis (Metastasis) 10/2013 - 04/2006
6	Pheochromocytoma 06/2011 - 04/2008
5	Colonic Neoplasms (Colon Cancer) 06/2013 - 01/2005
3	Prostatic Neoplasms (Prostate Cancer) 11/2015 - 05/2010
3	Ovarian Neoplasms (Ovarian Cancer) 01/2014 - 10/2012
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2014 - 09/2004
3	Hypertension (High Blood Pressure) 01/2014 - 10/2005
3	Lymphoma (Lymphomas) 01/2004 - 02/2002
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2015 - 07/2013
2	Lung Neoplasms (Lung Cancer) 04/2015 - 07/2013
2	Melanoma (Melanoma, Malignant) 01/2014 - 12/2013
2	Dermatitis 01/2014 - 07/2009
2	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2013 - 10/2010
2	Adenocarcinoma 11/2009 - 01/2004
2	Breast Neoplasms (Breast Cancer) 08/2009 - 01/2007
1	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 05/2016
1	Memory Disorders (Memory Loss) 02/2016
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2015

Drug/Important Bio-Agent (IBA)

15	PhytochemicalsIBA 09/2015 - 01/2004
15	AntioxidantsIBA 01/2015 - 01/2004
15	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 02/2013 - 12/2004
10	Matrix Metalloproteinases (MMPs)IBA 10/2013 - 01/2006
9	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2012 - 01/2006
8	Phosphotransferases (Kinase)IBA 09/2015 - 07/2008
7	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 04/2012 - 01/2004
6	IsoflavonesIBA 08/2013 - 05/2004
6	myricetinIBA 07/2011 - 09/2007
5	QuercetinIBA 05/2014 - 03/2005
5	FlavonoidsIBA 12/2013 - 10/2005
5	ResveratrolIBA 10/2013 - 11/2007
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2011 - 09/2007
5	PolyphenolsIBA 06/2011 - 01/2005
4	Proteins (Proteins, Gene)FDA Link 12/2015 - 05/2010
4	CarcinogensIBA 07/2011 - 02/2007
4	NF-kappa B (NF-kB)IBA 06/2011 - 12/2004
4	Ascorbic Acid (Vitamin C)FDA LinkGeneric 02/2008 - 01/2002
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 05/2016 - 04/2009
3	Cisplatin (Platino)FDA LinkGeneric 01/2014 - 10/2012
3	LuteolinIBA 10/2013 - 03/2010
3	ErbB Receptors (EGF Receptor)IBA 07/2013 - 07/2010
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2011 - 04/2009
3	Mitogen-Activated Protein KinasesIBA 06/2011 - 07/2008
3	kaempferolIBA 06/2011 - 08/2010
3	daidzeinIBA 04/2011 - 11/2007
3	Biological ProductsIBA 04/2011 - 10/2005
3	ProstaglandinsIBA 05/2010 - 10/2009
3	Gallic AcidIBA 08/2009 - 03/2005
3	procyanidin B2IBA 05/2009 - 04/2008
3	Acetylcysteine (Siran)FDA LinkGeneric 12/2006 - 01/2006
3	DNA (Deoxyribonucleic Acid)IBA 01/2006 - 02/2002
2	indole-3-carbinolIBA 10/2017 - 01/2014
2	3,3'-diindolylmethane (diindolylmethane)IBA 10/2017 - 01/2014
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 12/2015 - 07/2013
2	hirsutenoneIBA 11/2015 - 01/2014
2	Gefitinib (Iressa)FDA Link 04/2015 - 07/2013
2	caffeic acid phenethyl esterIBA 05/2014 - 02/2008
2	Propolis (Bee Bread)IBA 05/2014 - 02/2008
2	LipopolysaccharidesIBA 01/2014 - 12/2013
2	Pharmaceutical PreparationsIBA 12/2013 - 10/2005
2	isoangustone AIBA 12/2013 - 10/2013
2	3,3',4,5'-tetrahydroxystilbeneIBA 10/2013 - 08/2013
2	src-Family KinasesIBA 02/2013 - 06/2011
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2013 - 08/2010
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 09/2011 - 10/2009
2	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 06/2011 - 08/2009
2	Coffee FDA Link 06/2011 - 02/2009
2	Epidermal Growth Factor (EGF)IBA 04/2011 - 07/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2010 - 04/2010
2	CytokinesIBA 10/2010 - 07/2009
2	arseniteIBA 05/2010 - 10/2009
2	phenethyl isothiocyanate (PEITC)IBA 05/2010 - 12/2006
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 04/2010 - 01/2007
2	Prostaglandins EIBA 11/2009 - 10/2009
2	procyanidinIBA 05/2009 - 04/2008
2	Connexin 43 (Connexin43)IBA 03/2009 - 02/2008
2	CatalaseIBA 03/2009 - 03/2005
2	Conjugated Linoleic AcidsIBA 02/2007 - 01/2005
2	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2007 - 04/2006
2	2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate (AITC)IBA 04/2006 - 01/2006
2	VitaminsIBA 09/2004 - 01/2004
2	Peptides (Polypeptides)IBA 01/2004 - 12/2003
1	AcetylcholinesteraseIBA 02/2016
1	Scopolamine (Hyoscine)FDA Link 02/2016
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2015
1	Gemcitabine FDA Link 12/2015

Therapy/Procedure

9	Chemoprevention 01/2014 - 12/2003
2	Therapeutics 09/2015 - 01/2013
2	Oral Administration 01/2014 - 10/2013
1	East Asian Traditional Medicine (Oriental Medicine) 05/2016
1	Combination Drug Therapy (Combination Chemotherapy) 12/2015